Technical Papers

Separation Anxiety: Addressing Variation In Content Uniformity Data In Compression Processes

Eric Maynard

Pharmaceutical scientists are responsible for developing formulas and designing processes that ensure the content uniformity of tablets and capsules.  Unfortunately, a number of scientists who formulate products and who select and/or design processing equipment lack in-depth understanding of powder blending and segregation.  As a result, processes may be developed that are not capable of providing the required content uniformity of the dosage units.  This article focuses on identifying and addressing variation in content uniformity.